EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.79 | additional information | Homo sapiens | in the skeletal muscle at rest there is a high constitutive level of hormone-sensitive lipase activity, which is not a function of biopsy freezing. The combination of low adrenaline and Ca2+ levels and resting levels of insulin appears to dictate the levels of activity of hormone-sensitive lipase at rest. During the onset of low and moderate aerobic exercise enzyme activity is activated by contractions, in the apparent absence of increases in circulating adrenaline. However, adrenaline may contribute to the early activation of the enzyme during intense aerobic exercise. The contraction-induced activation appears to be related to the increase in protein kinase C and extracellular signal regulated kinase activity associated with Ca2+ and/or other unknown activators. As low- and moderate-intensity exercise continues beyond a few min, activation by adrenaline through the cAMP cascade and protein kinase A also appears to occur. With prolonged moderate-intensity exercise beyond 12 h and sustained high-intensity exercise, HSL activity decreases despite continuing increases in adrenaline, possibly as a result of increasing accumulation of free AMP, activation of AMP-activated kinase and phosphorylation of inhibitory sites on the hormone-sensitive lipase. Intramuscular factors dominate the control of hormone-sensitive lipase activity, with hormonal factors playing a smaller role | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.79 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.1.79 | phosphoprotein | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.79 | skeletal muscle | in the skeletal muscle at rest there is a high constitutive level of hormone-sensitive lipase activity, which is not a function of biopsy freezing. The combination of low adrenaline and Ca2+ levels and resting levels of insulin appears to dictate the levels of activity of hormone-sensitive lipase at rest. During the onset of low and moderate aerobic exercise enzyme activity is activated by contractions, in the apparent absence of increases in circulating adrenaline. However, adrenaline may contribute to the early activation of the enzyme during intense aerobic exercise. The contraction-induced activation appears to be related to the increase in protein kinase C and extracellular signal regulated kinase activity associated with Ca2+ and/or other unknown activators. As low- and moderate-intensity exercise continues beyond a few min, activation by adrenaline through the cAMP cascade and protein kinase A also appears to occur. With prolonged moderate-intensity exercise beyond 12 h and sustained high-intensity exercise, HSL activity decreases despite continuing increases in adrenaline, possibly as a result of increasing accumulation of free AMP, activation of AMP-activated kinase and phosphorylation of inhibitory sites on the hormone-sensitive lipase. Intramuscular factors dominate the control of hormone-sensitive lipase activity, with hormonal factors playing a smaller role | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.79 | additional information | in the skeletal muscle at rest there is a high constitutive level of hormone-sensitive lipase activity, which is not a function of biopsy freezing. The combination of low adrenaline and Ca2+ levels and resting levels of insulin appears to dictate the levels of activity of hormone-sensitive lipase at rest. During the onset of low and moderate aerobic exercise enzyme activity is activated by contractions, in the apparent absence of increases in circulating adrenaline. However, adrenaline may contribute to the early activation of the enzyme during intense aerobic exercise. The contraction-induced activation appears to be related to the increase in protein kinase C and extracellular signal regulated kinase activity associated with Ca2+ and/or other unknown activators. As low- and moderate-intensity exercise continues beyond a few min, activation by adrenaline through the cAMP cascade and protein kinase A also appears to occur. With prolonged moderate-intensity exercise beyond 12 h and sustained high-intensity exercise, HSL activity decreases despite continuing increases in adrenaline, possibly as a result of increasing accumulation of free AMP, activation of AMP-activated kinase and phosphorylation of inhibitory sites on the hormone-sensitive lipase. Intramuscular factors dominate the control of hormone-sensitive lipase activity, with hormonal factors playing a smaller role | Homo sapiens | ? | - |
? |